Health and care challenges combine social, political, economic and technological ambitions which necessitate a greater multidisciplinary understanding of the landscape/context in which they exist. These challenges are complex and difficult to describe while also highly inter-related, thus making possible solutions difficult to recognize due to their complex interdependencies. Such challenges require a multi-disciplinary approach in finding possible solutions. This multi-disciplinary approach includes the engagement of different knowledge bases and the combination of ‘hard’ sciences, social sciences, and the humanities. Overall, current health and care challenges stress the importance of a multi-disciplinary mindset for the exploration of possible solutions.